© 2016 Kelly:Feber Lab

  • Grey Facebook Icon
  • Grey Twitter Icon

PUBLICATIONS

April 15, 2018

Who Should Be Investigated for Haematuria? Results of a Contemporary Prospective Observational Study of 3556 Patients

Wei Shen Tan, Andrew Feber, Rachael Sarpong, Pramit Khetrapal, Simon Rodney, Rumana Jalil, Hugh Mostafid, Joanne Cresswell, James Hicks, Abhay Rane, Alastair Henderson, Dawn Watson, Jacob Cherian, Norman Williams, Chris Brew-Graves, John D. Kelly on behalf of DETECT I trial collaborators. European Urology, AOP

January 31, 2017

UroMark—a urinary biomarker assay for the detection of bladder cancer

Feber A, Dhami P, Dong L, de Winter P, Tan WS, Martínez-Fernández M, Paul DS, Hynes-Allen A, Rezaee S, Gurung P, Rodney S, Mehmood A, Villacampa F, de la Rosa F, Jameson C, Cheng KK, Zeegers MP, Bryan RT, James ND, Paramio JM, Freeman A, Beck S, Kelly JD. UroMark - A urinary biomarker assay for the detection of bladder cancer. Clin Epigenetics. 2017.

December 01, 2016

Human Papillomavirus Drives Tumor Development Throughout the Head and Neck: Improved Prognosis Is Associated With an Immune Response Largely Restricted to the Oropharynx.

Chakravarthy A, Henderson S, Thirdborough SM, Ottensmeier CH, Su X, Lechner M, Feber A, Thomas GJ, Fenton TR. Human Papillomavirus Drives Tumor Development Throughout the Head and Neck: Improved Prognosis Is Associated With an Immune Response Largely Restricted to the Oropharynx. J Clin Oncol. 2016 Dec;34(34):4132-4141. Epub 2016 Oct 31. PMID: 27863190.

November 30, 2016

Blood Transfusion Requirement and Not Preoperative Anemia Are Associated with Perioperative Complications Following Intracorporeal Robot-Assisted Radical Cystectomy.

Tan WS, Lamb BW, Khetrapal P, Tan MY, Tan MEL, Sridhar A, Cervi E, Rodney S, Busuttil G, Nathan S, Hines J, Shaw G, Mohammed A, Baker H, Briggs TP, Klein A, Richards T, Kelly JD. Blood Transfusion Requirement and not Preoperative Anaemia is associated with Perioperative Complications following Intracorporeal Robotic Assisted Radical Cystectomy. J Endourol. 2016 Nov 30. [Epub ahead of print]. PMID: 27901350.

November 07, 2016

Robotic Assisted Radical Cystectomy with Extracorporeal Urinary Diversion Does Not Show a Benefit over Open Radical Cystectomy: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.

Tan WS, Khetrapal P, Tan WP, Rodney S, Chau M, Kelly JD. A Systematic Review and Meta- analysis of Randomised Controlled Trials of Robotic Assisted Radical Cystectomy versus Open Radical Cystectomy. PLoS One. 2016 Nov 7;11(11):e0166221. PMID: 27820855.

June 11, 2016

Port-site metastases following robotic radical cystectomy: A systematic review and management options

Khetrapal P, Tan WS, Lamb B, Nathan S, Briggs T, Shankar A, Ramachandran N, Freeman A, Mitra A, Kelly JD. Port-site metastases following robotic radical cystectomy: A systematic review and management options. Clin Genitourin Cancer. DOI: http://dx.doi.org/10.1016/j.clgc.2016.06.012.

August 14, 2016

CSN1 Somatic Mutations in Penile Squamous Cell Carcinoma.

Feber A, Worth D, Chakravarthy A, de Winter P, Shah K, Arya M, Saqib M, Nigam R, Malone P, Tan WS, Rodney S, Freeman A, Jameson C, Wilson G, Powles T, Beck B, Fenton T, Sharp T, Muneer A, Beck S, Kelly JD.

SN1 somatic mutations in penile squamous cell carcinoma. Cancer Res. 2016 Jun 20. pii: canres.3134.2015. PMID: 27325650.

June 22, 2016

In-depth Critical Analysis of Complications Following Robot-assisted Radical Cystectomy with Intracorporeal Urinary Diversion

Tan WS, Lamb BW, Tan MY, Ahmad I, Sridhar A, Nathan S, Shaw G, Hines J, Briggs T, Kelly JD. Complications following Robotic Assisted Radical Cystectomy with Intracorporeal Urinary Diversion: An in Depth Critical Analysis of Technical and Systemic Complications. Eur Urol Focus. DOI: 10.1016/j.euf.2016.06.002.

May 31, 2016

Management of non-muscle invasive bladder cancer: A comprehensive analysis of guidelines from the United States, Europe and Asia.

Tan WS, Rodney S, Lamb BW, Feneley M, Kelly JD. Management of Non-muscle Invasive Bladder Cancer: A Comprehensive Analysis of Guidelines from the United States, Europe and Asia. Cancer Treat Rev. 2016 May 10;47:22-31. PMID: 27231966.

August 31, 2016

Benefits of robotic cystectomy with intracorporeal diversion for patients with low cardiorespiratory fitness: A prospective cohort study.

Lamb BW, Tan WS, Eneje P, Bruce D, Jones A, Ahmad I, Sridhar A, Baker H, Briggs T, Hines JE, Nathan S, Martin D, Stephens R, Kelly JD. Benefits of robotic cystectomy with intracorporeal diversion for patients with low cardiorespiratory fitness: a prospective cohort study. Urol Oncol. 2016 May 16. pii: S1078-1439(16)30016- 3. PMID: 27197920.

May 31, 2016

Analysis of open and intracorporeal robotic assisted radical cystectomy shows no significant difference in recurrence patterns and oncological outcomes.

Tan WS, Sridhar A, Ellis G, Lamb BW, Goldstraw M, Nathan S, Hines J, Cathcart P, Briggs T, Kelly JD. Analysis of open and intracorporeal robotic cystectomy shows no significant difference in recurrence patterns and oncological outcomes. Urol Oncol. 2016 Jun; 34(6):257.e1-9. doi: 10.1016/j.urolonc.2016.02.010. Epub 2016 Mar 8. PMID:26968561.

June 10, 2016

Combined 2D and 3D tracking of surgical instruments for minimally invasive and robotic-assisted surgery.

Du X, Allan M, Dore A, Ourselin S, Hawkes D, Kelly JD, Stoyanov D.Combined 2D and 3D tracking of surgical instruments for minimally invasive and robotic-assisted surgery. Int J Comput Assist Radiol Surg. 2016 Jun;11(6):1109-19. doi: 10.1007/s11548-016- 1393-4. PMID: 27038963.

March 13, 2016

Recovery of Baseline Erectile Function in Men Following Radical Prostatectomy for High-Risk Prostate Cancer: A Prospective Analysis Using Validated Measures.

Sridhar AN, Cathcart PJ, Yap T, Hines J, Nathan S, Briggs TP, Kelly JD, Minhas S. Recovery of Baseline Erectile Function in Men Following Radical Prostatectomy for High-Risk Prostate Cancer: A Prospective Analysis Using Validated Measures. J Sex Med. 2016 Mar;13(3):435-43. doi: 10.1016/j.jsxm.2016.01.005. PMID: 26944466.

February 17, 2016

Global hypomethylation in myeloma is associated with poor prognosis.

Sive JI, Feber A, Smith D, Quinn J, Beck S, Yong K. Global hypomethylation in myeloma is associated with poor prognosis. Br J Haematol. 2016 Feb;172(3):473-5. doi: 10.1111/bjh.13506. PMID: 26010672.

February 16, 2016

Evolution of the neobladder: A critical review of open and intracorporeal neobladder reconstruction techniques.

Tan WS, Lamb BW, Kelly JD. Evolution of Neobladder Reconstruction: A Critical Review of Open and Intracorporeal Neobladder Reconstruction Techniques. Scand J Urol. 2016 Feb 16:1-9. PMID:26882458.

January 01, 2016

Prognostic Impact of Novel Molecular Subtypes of Small Intestinal Neuroendocrine Tumor.

Karpathakis A, Dibra H, Pipinikas C, Feber A, Morris T, Francis J, Oukrif D, Mandair D, Pericleous M, Mohmaduvesh M, Serra S, Ogunbiyi O, Novelli M, Luong T, Asa SL, Kulke M, Toumpanakis C, Meyer T, Caplin M, Meyerson M, Beck S, Thirlwell C. Prognostic Impact of Novel Molecular Subtypes of Small Intestinal Neuroendocrine Tumor. Clin Cancer Res. 2016 Jan 1;22(1):250-8. doi: 10.1158/1078-0432.CCR- 15-0373. PMID: 26169971.

January 19, 2016

Why do patients decline surgical trials? Findings from a qualitative interview study embedded in the Cancer Research UK BOLERO trial (Bladder cancer: Open versus Lapararoscopic or RObotic cystectomy).

Harrop E, Kelly J, Griffiths G, Casbard A, Nelson A; Published on behalf of the BOLERO Trial Management Group (TMG). Why do patients decline surgical trials? Findings from a qualitative interview study embedded in the Cancer Research UK BOLERO trial (Bladder cancer: Open versus Lapararoscopic or RObotic cystectomy). Trials. 2016 Jan 19;17:35. doi: 10.1186/s13063-016- 1173-z. PMID: 26787177.

December 15, 2015

A donor-specific epigenetic classifier for acute graft-versus-host disease severity in hematopoietic stem cell transplantation.

Paul DS, Jones A, Sellar RS, Mayor NP, Feber A, Webster AP, Afonso N, Sergeant R, Szydlo RM, Apperley JF, Widschwendter M, Mackinnon S, Marsh SG, Madrigal JA, Rakyan VK, Peggs KS, Beck S. A donor-specific epigenetic classifier for acute graft-versus- host disease severity in hematopoietic stem cell transplantation. Genome Med. 2015 Dec 15;7:128. doi: 10.1186/s13073-015- 0246-z. PMID: 26669438.

December 08, 2015

A Polycomb-mir200 loop regulates clinical outcome in bladder cancer.

Martínez-Fernández M, Dueñas M, Feber A, Segovia C, García-Escudero R, Rubio C, López- Calderón FF, Díaz-García C, Villacampa F, Duarte J, Gómez-Rodriguez MJ, Castellano D, Rodriguez-Peralto JL, de la Rosa F, Beck S, Paramio JM. A Polycomb-mir200 loop regulates clinical outcome in bladder cancer. Oncotarget. 2015 Dec 8;6(39):42258-75. doi: 10.18632/oncotarget.5546. PMID: 26517683.

November 30, 2015

Complications of Radical Cystectomy and Orthotopic Reconstruction.

Tan WS, Lamb BW, Kelly JD. Complications of Radical Cystectomy and Orthotopic Reconstruction. Adv Urol. 2015;2015:323157. PMID:26697063.

November 10, 2015

Glioblastoma Stem Cells Respond to Differentiation Cues but Fail to Undergo Commitment and Terminal Cell-Cycle Arrest.

Carén H, Stricker SH, Bulstrode H, Gagrica S, Johnstone E, Bartlett TE, Feber A, Wilson G, Teschendorff AE, Bertone P, Beck S, Pollard SM. Glioblastoma Stem Cells Respond to Differentiation Cues but Fail to Undergo Commitment and Terminal Cell-Cycle Arrest. Stem Cell Reports. 2015 Nov 10;5(5):829-42. PMID: 26607953.

November 01, 2015

Robot-assisted intracorporeal pyramid neobladder.

Tan WS, Sridhar A, Goldstraw M, Zacharakis E, Nathan S, Hines J, Cathcart P, Briggs T, Kelly JD. Robot Assisted Intracorporeal Pyramid Neo-bladder. BJU Int. 2015 Nov;116(5):771-9. PMID:26033321.

October 07, 2015

Analysis of the Polycomb-related lncRNAs HOTAIR and ANRIL in bladder cancer.

Martínez-Fernández M, Feber A, Dueñas M, Segovia C, Rubio C, Fernandez M, Villacampa F, Duarte J, López-Calderón FF, Gómez-Rodriguez MJ, Castellano D, Rodriguez-Peralto JL, de la Rosa F, Beck S, Paramio JM. Analysis of the Polycomb-related lncRNAs HOTAIR and ANRIL in bladder cancer. Clin Epigenetics. 2015 Oct 8;7:109. doi: 10.1186/s13148-015- 0141- x. PMID: 26457124.

September 30, 2015

Aggressive Angiomyxoma of the Bladder Neck Requiring Local Excision and Mitrofanoff Formation.

Davari M, Lamb BW, Chowdhury S, Jameson C, Kelly JD, Greenwell T. Aggressive Angiomyxoma of the Bladder Neck Requiring Local Excision and Mitrofanoff Formation. Case Rep Urol. 2015; 2015:819243. doi: 10.1155/2015/819243. PMID: 26605101.

June 21, 2015

Epigenetic dysregulation and poorer prognosis in DAXX-deficient pancreatic neuroendocrine tumours.

Pipinikas CP, Dibra H, Karpathakis A, Feber A, Novelli M, Oukrif D, Fusai G, Valente R, Caplin M, Meyer T, Teschendorff A, Bell C, Morris TJ, Salomoni P, Luong TV, Davidson B, Beck S, Thirlwell C. Epigenetic dysregulation and poorer prognosis in DAXX-deficient pancreatic neuroendocrine tumours. Endocr Relat Cancer. 2015 Jun;22(3):L13-8. doi: 10.1530/ERC-15- 0108. PMID: 25900181.

June 03, 2015

PREVENTT: preoperative intravenous iron to treat anaemia in major surgery: study protocol for a randomised controlled trial.

Richards T, Clevenger B, Keidan J, Collier T, Klein AA, Anker SD, Kelly JD. PREVENTT: preoperative intravenous iron to treat anaemia in major surgery: study protocol for a randomised controlled trial. Trials. 2015 Jun 4;16:254. doi: 10.1186/s13063-015- 0774-2. PMID: 26041028.

June 30, 2015

Achieving Quality Assurance of Prostate Cancer Surgery During Reorganisation of Cancer Services.

Cathcart P, Sridhara A, Ramachandan N, Hines J, Briggs, Nathan S, Kelly JD. Achieving quality assurance of prostate cancer surgery during reorganisation of cancer services. Eur Urol. 2015 Jul;68(1):22-9. doi: 10.1016/j.eururo.2015.02.028. PMID: 25770482.

April 30, 2015

Molecular markers in penile cancer.

Rodney S, Feber A, Arya M, Muneer A. Molecular markers in penile cancer. Curr Probl Cancer. 2015 May-Jun;39(3):137- 45. doi: 10.1016/j.currproblcancer.2015.03.005. PMID: 26076980.

March 01, 2015

Epigenetics markers of metastasis and HPV-induced tumorigenesis in penile cancer.

Feber A, Arya M, de Winter P, Saqib M, Nigam R, Malone P, Tan WS, Rodney S, Freeman A, Jameson C, Muneer A, Beck S, Kelly JD. Epigenetics markers of metastasis and HPV induced tumourigenesis in penile cancer. Clin Cancer Res. 2015 Mar 1;21(5):1196-206. PMID:25538261.

February 01, 2015

Loss of expression of the tumour suppressor gene AIMP3 predicts survival following radiotherapy in muscle-invasive bladder cancer.

Gurung PM, Veerakumarasivam A, Wiliamson M, Counsell N, Douglas J, Tan WS, Feber A, Crabb S, Short SC, Freeman A, Powles T, Hoskin PJ, West CM, Kelly JD. Loss of Expression of the Tumour Suppressor Gene AIMP3 Predicts Survival Following Radiotherapy in Muscle-Invasive Bladder Cancer. Int J Cancer. 2015 Feb 1;136(3):709-20. PMID:24917520.

December 12, 2014

Assessment of patient-derived tumour xenografts (PDXs) as a discovery tool for cancer epigenomics.

Guilhamon P, Butcher LM, Presneau N, Wilson GA, Feber A, Paul DS, Schütte M, Haybaeck J, Keilholz U, Hoffman J, Ross MT, Flanagan AM, Beck S. Assessment of patient-derived tumour xenografts (PDXs) as a discovery tool for cancer epigenomics. Genome Med. 2014 Dec 12;6(12):116. doi: 10.1186/s13073-014- 0116-0. PMID: 25587359.

December 01, 2014

Validation and reliability testing of the EORTC QLQ-NMIBC24 questionnaire module to assess patient-reported outcomes in non-muscle-invasive bladder cancer.

Blazeby J M, Hall E, Aaronson N K, Lloyd L, Waters R, Kelly J D and Fayers P. Validation and Reliability Testing of the EORTC QLQ-NMIBC24 Questionnaire Module to Assess Patient-reported Outcomes in Non–Muscle-invasive Bladder Cancer. Eur Urol. 2014 Dec;66(6):1148-56. doi: 10.1016/j.eururo.2014.02.034. PMID: 24612661.

May 08, 2014

Assessment of RainDrop BS-seq as a method for large-scale, targeted bisulfite sequencing.

Paul DS, Guilhamon P, Karpathakis A, Butcher LM, Thirlwell C, Feber A, Beck S. Assessment of RainDrop BS-seq as a method for large-scale, targeted bisulfite sequencing. Epigenetics. 2014 May;9(5):678-84. doi: 10.4161/epi.28041. PMID: 24518816.

March 05, 2014

Human-specific epigenetic variation in the immunological Leukotriene B4 Receptor (LTB4R/BLT1) implicated in common inflammatory diseases.

Wilson GA, Butcher LM, Foster HR, Feber A, Roos C, Walter L, Woszczek G, Beck S, Bell CG. Human-specific epigenetic variation in the immunological Leukotriene B4 Receptor (LTB4R/BLT1) implicated in common inflammatory diseases. Genome Med. 2014 Mar 5;6(3):19. doi: 10.1186/gm536. PMID: 24598577.

February 01, 2014

ChAMP: 450k Chip Analysis Methylation Pipeline.

Morris TJ, Butcher LM, Feber A, Teschendorff AE, Chakravarthy AR, Wojdacz TK, Beck S. ChAMP: 450k Chip Analysis Methylation Pipeline. Bioinformatics. 2014 Feb 1;30(3):428-30. doi: 10.1093/bioinformatics/btt684. PMID: 24336642.

February 03, 2014

Using high-density DNA methylation arrays to profile copy number alterations.

Feber A, Guilhamon P, Lechner M, Fenton T, Wilson GA, Thirlwell C, , Thirlwell C , Morris TJ, Flanagan AM , Teschendorff AE , Kelly JD , Beck S. Using high-density DNA methylation arrays to profile copy number alterations. Genome Biol. 2014 Feb 3;15(2):R30. doi: 10.1186/gb-2014- 15-2- r30. PMID: 24490765.

January 31, 2014

Molecular aspects of upper tract urothelial carcinoma.

Patel N, Arya M, Muneer A, Powles T, Sullivan M, Hines J, Kelly J. Molecular aspects of upper tract urothelial carcinoma. Urol Oncol. 2014 Jan;32(1):28.e11-20. doi: 10.1016/j.urolonc.2012.10.002. PMID: 23428541.

December 24, 2013

Long-term trends in incidence, survival and mortality of primary penile cancer in England.

Arya M, Li R, Pegler K, Sangar V, Kelly JD, Minhas S, Muneer A, Coleman MP. Long-term trends in incidence, survival and mortality of primary penile cancer in England. Cancer Causes Control. 2013 Dec;24(12):2169-76. doi: 10.1007/s10552-013- 0293-y. PMID: 24101363.

November 10, 2013

Innovation: London Cancer-multidisciplinary approach to urological cancer.

Powles T, Kelly JD. Innovation: London Cancer-multidisciplinary approach to urological cancer. Nat Rev Clin Oncol. 2013 Nov;10(11):609-10. doi: 10.1038/nrclinonc.2013.179. PMID: 24101123.

September 07, 2013

Integrated virus-host methylome analysis in head and neck squamous cell carcinoma.

Wilson GA, Lechner M, Köferle A, Caren H, Butcher LM, Feber A, Fenton T, Jay A, Boshoff C, Beck S. Integrated virus-host methylome analysis in head and neck squamous cell carcinoma. Epigenetics. 2013 Sep;8(9):953-61. doi: 10.4161/epi.25614. PMID: 23867721.

July 31, 2013

Comparison of robot-assisted and laparoscopic pelvic lymphadenectomy in penile cancer patients with stage N2/N3 inguinal disease

Buxton J, Taylor H, Basnett G, Nigam R, Minhas S, Kelly JD, Muneer A. Comparison of robot-assisted and laparoscopic pelvic lymphadenectomy in penile cancer patients with stage N2/N3 inguinal disease. Int J Surg. 2013 Aug; 11(7): 564. doi: http://dx.doi.org/10.1016/j.ijsu.2013.05.014.

April 20, 2013

Meta-analysis of IDH-mutant cancers identifies EBF1 as an interaction partner for TET2.

Guilhamon P, Eskandarpour M, Halai D, Wilson GA, Feber A, Teschendorff AE, Gomez V, Hergovich A, Tirabosco R, Fernanda Amary M, Baumhoer D, Jundt G, Ross MT, Flanagan AM, Beck S. Meta-analysis of IDH-mutant cancers identifies EBF1 as an

interaction partner for TET2. Nat Commun. 2013;4:2166. doi: 10.1038/ncomms3166. PMID:23863747.

May 28, 2013

Targeted next-generation sequencing of head and neck squamous cell carcinoma identifies novel genetic alterations in HPV+ and HPV- tumors.

Lechner M, Frampton GM, Fenton T, Feber A, Palmer G, Jay A, Pillay N, Forster M, Cronin MT, Lipson D, Miller VA, Brennan TA, Henderson S, Vaz F, O'Flynn P, Kalavrezos N, Yelensky R, Beck S, Stephens PJ, Boshoff C. Targeted next-generation sequencing of head and neck squamous cell carcinoma identifies novel genetic alterations in HPV+ and HPV- tumors. Genome Med. 2013 May 29;5(5):49. doi: 10.1186/gm453. PMID: 23718828.

March 06, 2013

Malignant and premalignant lesions of the penis.

Arya M, Kalsi J, Kelly J, Muneer A. Malignant and premalignant lesions of the penis. BMJ. 2013;346:f1149. doi: 10.1136/bmj.f1149. PMID: 23468288.

March 31, 2013

Toward detection and localization of instruments in minimally invasive surgery.

Allan M, Ourselin S, Thompson S, Hawkes DJ, Kelly J, Stoyanov D. Toward detection and localization of instruments in minimally invasive surgery. IEEE Trans Biomed Eng. 2013 Apr;60(4):1050-8. doi: 10.1109/TBME.2012.2229278. PMID: 23192482.

March 15, 2013

Widespread resetting of DNA methylation in glioblastoma-initiating cells suppresses malignant cellular behavior in a lineage-dependent manner.

Stricker SH, Feber A, Engström PG, Carén H, Kurian KM, Takashima Y, Watts C, Way M, Dirks P, Bertone P, Smith A, Beck S, Pollard SM. Widespread resetting of DNA methylation in glioblastoma-initiating cells suppresses malignant cellular behavior in a lineage-dependent manner. Genes Dev. 2013 Mar 15;27(6):654-69. doi: 10.1101/gad.212662.112. PMID: 23512659.

February 21, 2013

Keypad mobile phones are associated with a significant increased risk of microbial contamination compared to touch screen phones

Pal P, Roy A, Moore G, Muzslay M, Lee E, Alder S, Wilson P, Powles T, Wilson P, Kelly JD. Keypad mobile phones are associated with a significant increased risk of microbial contamination compared to touch screen phones. J Inf Prev. 2013; 14 (2): 65-68. 10.1177/1757177413475903.

February 05, 2013

Identification and functional validation of HPV-mediated hypermethylation in head and neck squamous cell carcinoma.

Lechner M, Fenton T, West J, Wilson G, Feber A, Henderson S, Thirlwell C, Dibra HK, Jay A, Butcher L, Chakravarthy AR, Gratrix F, Patel N, Vaz F, O'Flynn P, Kalavrezos N, Teschendorff AE, Boshoff C, Beck S. Identification and functional validation of HPV-mediated hypermethylation in head and neck squamous cell carcinoma. Genome Med. 2013 Feb 5;5(2):15. doi: 10.1186/gm419. PMID: 23419152.

November 13, 2012

Comments on: Interpretation of genome-wide infinium methylation data from ligated DNA in formalin-fixed paraffin-embedded paired tumor and normal tissue

Thirlwell C, Feber A, Lechner M, Teschendorff AE, Beck S. Comments on: Interpretation of genome-wide infinium methylation data from ligated DNA in formalin-fixed paraffin-embedded paired tumor and normal tissue. BMC Res Notes. 2012 Nov 13;5:631. doi: 10.1186/1756- 0500-5- 631. PMID: 23148593.

November 22, 2012

A functional methylome map of ulcerative colitis.

Häsler R, Feng Z, Bäckdahl L, Spehlmann ME, Franke A, Teschendorff A, Rakyan VK, Down TA, Wilson GA, Feber A, Beck S, Schreiber S, Rosenstiel P. A functional methylome map of ulcerative colitis. Genome Res. 2012 Nov;22(11):2130-7. doi: 10.1101/gr.138347.112. PMID: 22826509.

September 10, 2012

Photodynamic diagnostic cystoscopy.

July 31, 2012

The JmjC domain-containing histone demethylase KDM3A is a positive regulator of the G1/S transition in cancer cells via transcriptional regulation of the HOXA1 gene.

Cho HS, Toyokawa G, Daigo Y, Hayami S, Masuda K, Ikawa N, Yamane Y, Maejima K, Tsunoda T, Field HI, Kelly JD, Neal DE, Ponder BA, Maehara Y, Nakamura Y, Hamamoto R. The JmjC domain-containing histone demethylase KDM3A is a positive regulator of the G1/S transition in cancer cells via transcriptional regulation of the HOXA1 gene. Int J Cancer. 2012 Aug 1;131(3):E179-89. doi: 10.1002/ijc.26501. PMID: 22020899.

July 08, 2012

Bladder cancer diagnosis and identification of clinically significant disease by combined urinary detection of Mcm5 and nuclear matrix protein 22.

Kelly JD, Dudderidge TJ, Wollenschlaeger A, Okoturo O, Burling K, Tulloch F, Halsall I, Prevost T, Prevost AT, Vasconcelos JC, Robson W, Leung Y, Vasdev N, Pickard RS, Williams GH, Stoeber K. Bladder cancer diagnosis and identification of clinically significant disease by combined urinary detection of mcm5 and nuclear matrix protein 22. PLoS One. 2012;7(7):e40305. doi: 10.1371/journal.pone.0040305. PMID: 22792272

July 11, 2012

Resources for methylome analysis suitable for gene knockout studies of potential epigenome modifiers.

Wilson GA, Dhami P, Feber A, Cortázar D, Suzuki Y, Schulz R, Schär P, Beck S. Resources for methylome analysis suitable for gene knockout studies of potential epigenome modifiers. Gigascience. 2012 Jul 12;1(1):3. doi: 10.1186/2047-217X- 1-3. PMID: 23587164.

October 03, 2011

Boxing bladder cancer with COX-2-specific inhibition.

Kelly JD, Hall E. Boxing bladder cancer with COX-2- specific inhibition. Cancer Prev Res (Phila). 2011 Oct;4(10):1534-5. doi: 10.1158/1940-6207.CAPR- 11-0409. PMID: 21896649.

December 04, 2011

The histone demethylase JMJD2B plays an essential role in human carcinogenesis through positive regulation of cyclin-dependent kinase 6.

Toyokawa G, Cho HS, Iwai Y, Yoshimatsu M, Takawa M, Hayami S, Maejima K, Shimizu N, Tanaka H, Tsunoda T, Field HI, Kelly JD, Neal DE, Ponder BA, Maehara Y, Nakamura Y, Hamamoto R. The histone demethylase JMJD2B plays an essential role in human carcinogenesis through positive regulation of cyclin-dependent kinase 6. Cancer Prev Res (Phila). 2011 Dec;4(12):2051-61. doi: 10.1158/1940-6207.CAPR- 11-0290. PMID: 21930796.

August 12, 2011

Enhanced expression of EHMT2 is involved in the proliferation of cancer cells through negative regulation of SIAH1.

Cho HS, Kelly JD, Hayami S, Toyokawa G, Takawa M, Yoshimatsu M, Tsunoda T, Field HI, Neal DE, Ponder BA, Nakamura Y, Hamamoto R. Enhanced expression of EHMT2 is involved in the proliferation of cancer cells through negative regulation of SIAH1. Neoplasia. 2011 Aug;13(8):676-84. PMID: 21847359.

October 12, 2011

Histone Lysine Methyltransferase Wolf-Hirschhorn Syndrome Candidate 1 Is Involved in Human Carcinogenesis through Regulation of the Wnt Pathway

Toyokawa G, Cho HS, Masuda K, Yamane Y, Yoshimatsu M, Hayami S, Takawa M, Iwai Y, Daigo Y, Tsuchiya E, Tsunoda T, Field HI, Kelly JD, Neal DE, Maehara Y, Ponder BA, Nakamura Y, Hamamoto R. Histone lysine methyltransferase Wolf-Hirschhorn syndrome candidate 1 is involved in human carcinogenesis through regulation of the Wnt pathway. Neoplasia. 2011 Oct;13(10):887-98. PMID: 22028615.

April 30, 2011

MicroRNA prognostic signature for nodal metastases and survival in esophageal adenocarcinoma.

Feber A, Xi L, Pennathur A, Gooding WE, Bandla S, Wu M, Luketich JD, Godfrey TE, Litle VR. MicroRNA prognostic signature for nodal metastases and survival in esophageal adenocarcinoma. Ann Thorac Surg. 2011 May;91(5):1523-30. doi: 10.1016/j.athoracsur.2011.01.056. PMID: 21420070.

March 31, 2011

Comparative methylome analysis of benign and malignant peripheral nerve sheath tumors.

Feber A, Wilson GA, Zhang L, Presneau N, Idowu B, Down TA, Rakyan VK, Noon LA, Lloyd AC, Stupka E, Schiza V, Teschendorff AE, Schroth GP, Flanagan A, Beck S. Comparative methylome analysis of benign and malignant peripheral nerve sheath tumors. Genome Res. 2011 Apr;21(4):515-24. doi: 10.1101/gr.109678.110. PMID: 21324880.

February 01, 2011

Dysregulation of PRMT1 and PRMT6, Type I arginine met