The Kelly:Feber lab is interested in understanding how genetic and epigenetic alterations affect the development and progression of urological cancers (cancer of the male and female urinary tract system and the male reproductive organs), and how these alterations can be used to improve patient outcomes.
Through understanding how these alterations work we are able to find new ways of identifying cancers early and predicting the way in which cancer will develop and respond to treatment.
All cancers begin when one or more genes in a cell are mutated, or changed. How these changes arise in cancer can take several forms. At the Kelly:Feber Lab, we look at two types of cancer specific DNA alterations:
Genomic alterations – where the DNA in a cell is altered or mutated, stopping the cell for making the a gene properly
Epigenomic alterations – these changes do not affect the DNA sequence itself, but affect how and when genes are switched on and off
Our lab is focused on using these cancer specific changes to identify new ways to detect the presence of cancer from easy to acquire body fluids like urine and blood.